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AMG-706

AMG-706

Synonyms

Sources	Names Used
GDSC1000	AMG-706
FIMM	Motesanib
PharmacoGx	AMG-706

External IDs

Database	Identifier
Smiles:	CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
Inchikey:	RAHBGWKEPAQNFF-UHFFFAOYSA-N
Pubchem:	11667893

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to AMG-706

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	BAAT	FIMM	pan-cancer	AAC	0.61	0.0001
mRNA	KMT2A	FIMM	pan-cancer	AAC	0.56	0.0001
mRNA	TRH	FIMM	pan-cancer	AAC	0.58	0.0001
mRNA	ERG	FIMM	pan-cancer	AAC	0.6	0.0002
mRNA	SLC16A8	FIMM	pan-cancer	AAC	0.56	0.0003
mRNA	LRRC3	FIMM	pan-cancer	AAC	0.62	0.0003
mRNA	A1CF	FIMM	pan-cancer	AAC	0.66	0.0003
mRNA	NR5A2	FIMM	pan-cancer	AAC	0.55	0.0003
mRNA	RAI1	FIMM	pan-cancer	AAC	0.53	0.0004
mRNA	SEL1L3	FIMM	pan-cancer	AAC	-0.56	0.0004

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