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AMG-706

AMG-706

Synonyms

Sources	Names Used
GDSC1000	AMG-706
FIMM	Motesanib
PharmacoGx	AMG-706

External IDs

Database	Identifier
Smiles:	CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
Inchikey:	RAHBGWKEPAQNFF-UHFFFAOYSA-N
Pubchem:	11667893

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to AMG-706

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	HMOX1	GDSC1000	pan-cancer	AAC	0.13	0.0004
mRNA	RPIA	GDSC1000	pan-cancer	AAC	-0.14	0.0004
mRNA	BTG3	GDSC1000	pan-cancer	AAC	-0.12	0.0005
mRNA	KCTD15	GDSC1000	pan-cancer	AAC	0.13	0.0005
mRNA	PDGFRB	GDSC1000	pan-cancer	AAC	0.14	0.0005
mRNA	AP5B1	GDSC1000	pan-cancer	AAC	0.13	0.0005
mRNA	MLLT10	FIMM	pan-cancer	AAC	0.56	0.0005
mRNA	ITGB3BP	GDSC1000	pan-cancer	AAC	-0.13	0.0005
mRNA	TM4SF1	GDSC1000	pan-cancer	AAC	0.16	0.0005
mRNA	SLC39A14	GDSC1000	pan-cancer	AAC	0.12	0.0005

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