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AZD-2281

AZD-2281

Synonyms

Sources	Names Used
GDSC1000, FIMM	Olaparib
CTRPv2	olaparib
PharmacoGx	AZD-2281

External IDs

Database	Identifier
Smiles:	C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
Inchikey:	FDLYAMZZIXQODN-UHFFFAOYSA-N
Pubchem:	23725625

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to AZD-2281

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	CRAMP1	CTRPv2	pan-cancer	AAC	0.23	2e-10
mRNA	BAHCC1	CTRPv2	pan-cancer	AAC	0.22	3e-10
mRNA	ZFP1	CTRPv2	pan-cancer	AAC	0.23	3e-10
mRNA	SP4	CTRPv2	pan-cancer	AAC	0.22	5e-10
mRNA	PRKX	CTRPv2	pan-cancer	AAC	0.23	5e-10
mRNA	KLHL15	CTRPv2	pan-cancer	AAC	0.22	7e-10
mRNA	MTR	CTRPv2	pan-cancer	AAC	0.23	8e-10
mRNA	ZBTB5	CTRPv2	pan-cancer	AAC	0.22	8e-10
mRNA	KHDRBS1	CTRPv2	pan-cancer	AAC	0.22	9e-10
mRNA	ARHGAP19	CTRPv2	pan-cancer	AAC	0.26	1e-09

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