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RDEA119

RDEA119

Synonyms

Sources	Names Used
GDSC1000	RDEA119
FIMM	Refametinib
PharmacoGx	RDEA119

External IDs

Database	Identifier
Smiles:	COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)CC(CO)O)NC3=C(C=C(C=C3)I)F)F)F
Inchikey:	RDSACQWTXKSHJT-NSHDSACASA-N
Pubchem:	44182295

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to RDEA119

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	POU2F1	GDSC1000	pan-cancer	AAC	-0.19	6e-08
mRNA	NAGA	GDSC1000	pan-cancer	AAC	0.17	6e-08
mRNA	ZFP1	GDSC1000	pan-cancer	AAC	-0.18	6e-08
mRNA	EREG	GDSC1000	pan-cancer	AAC	0.18	6e-08
mRNA	USP11	GDSC1000	pan-cancer	AAC	-0.17	6e-08
mRNA	TET1	GDSC1000	pan-cancer	AAC	-0.18	6e-08
mRNA	CSRNP3	GDSC1000	pan-cancer	AAC	-0.18	6e-08
mRNA	GNG11	GDSC1000	pan-cancer	AAC	0.2	6e-08
mRNA	PIAS4	GDSC1000	pan-cancer	AAC	-0.17	7e-08
mRNA	SIGLEC12	GDSC1000	pan-cancer	AAC	0.17	7e-08

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