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RDEA119

RDEA119

Synonyms

Sources	Names Used
GDSC1000	RDEA119
FIMM	Refametinib
PharmacoGx	RDEA119

External IDs

Database	Identifier
Smiles:	COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)CC(CO)O)NC3=C(C=C(C=C3)I)F)F)F
Inchikey:	RDSACQWTXKSHJT-NSHDSACASA-N
Pubchem:	44182295

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to RDEA119

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	CD300LF	GDSC1000	pan-cancer	AAC	0.17	3e-08
mRNA	ELOVL4	GDSC1000	pan-cancer	AAC	-0.18	3e-08
mRNA	CTNNA1	GDSC1000	pan-cancer	AAC	0.2	3e-08
mRNA	IGFBPL1	GDSC1000	pan-cancer	AAC	-0.2	3e-08
mRNA	ZNF775	GDSC1000	pan-cancer	AAC	-0.19	3e-08
mRNA	DTX3L	GDSC1000	pan-cancer	AAC	0.18	3e-08
mRNA	TGIF1	GDSC1000	pan-cancer	AAC	0.2	3e-08
mRNA	EFR3A	GDSC1000	pan-cancer	AAC	0.17	3e-08
mRNA	NOVA1	GDSC1000	pan-cancer	AAC	-0.18	3e-08
mRNA	PARD6A	GDSC1000	pan-cancer	AAC	-0.18	3e-08

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