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RDEA119

RDEA119

Synonyms

Sources	Names Used
GDSC1000	RDEA119
FIMM	Refametinib
PharmacoGx	RDEA119

External IDs

Database	Identifier
Smiles:	COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)CC(CO)O)NC3=C(C=C(C=C3)I)F)F)F
Inchikey:	RDSACQWTXKSHJT-NSHDSACASA-N
Pubchem:	44182295

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to RDEA119

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	S100A16	GDSC1000	pan-cancer	AAC	0.3	6e-13
mRNA	TMBIM1	GDSC1000	pan-cancer	AAC	0.3	3e-17
mRNA	S100A6	GDSC1000	pan-cancer	AAC	0.3	5e-17
mRNA	CD44	GDSC1000	pan-cancer	AAC	0.3	6e-20
mRNA	CD63	GDSC1000	pan-cancer	AAC	0.31	1e-15
mRNA	LGALS3	GDSC1000	pan-cancer	AAC	0.31	2e-18
mRNA	CST3	GDSC1000	pan-cancer	AAC	0.31	2e-17
mRNA	SNX9	GDSC1000	pan-cancer	AAC	0.31	4e-15
mRNA	TNFRSF12A	GDSC1000	pan-cancer	AAC	0.32	1e-12
mRNA	CAPN2	GDSC1000	pan-cancer	AAC	0.32	2e-15

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