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RDEA119

RDEA119

Synonyms

Sources	Names Used
GDSC1000	RDEA119
FIMM	Refametinib
PharmacoGx	RDEA119

External IDs

Database	Identifier
Smiles:	COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)CC(CO)O)NC3=C(C=C(C=C3)I)F)F)F
Inchikey:	RDSACQWTXKSHJT-NSHDSACASA-N
Pubchem:	44182295

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to RDEA119

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	TLR4	GDSC1000	pan-cancer	AAC	0.2	7e-11
mRNA	ADAM9	GDSC1000	pan-cancer	AAC	0.26	7e-11
mRNA	TSPYL4	GDSC1000	pan-cancer	AAC	-0.21	8e-11
mRNA	SCG3	GDSC1000	pan-cancer	AAC	-0.22	8e-11
mRNA	FBXO21	GDSC1000	pan-cancer	AAC	-0.22	9e-11
mRNA	MPO	GDSC1000	pan-cancer	AAC	0.19	9e-11
mRNA	PIEZO1	GDSC1000	pan-cancer	AAC	0.21	9e-11
mRNA	TGFB1	GDSC1000	pan-cancer	AAC	0.22	1e-10
mRNA	ANXA2	GDSC1000	pan-cancer	AAC	0.25	1e-10
mRNA	ZNF711	GDSC1000	pan-cancer	AAC	-0.21	1e-10

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