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RDEA119

RDEA119

Synonyms

Sources	Names Used
GDSC1000	RDEA119
FIMM	Refametinib
PharmacoGx	RDEA119

External IDs

Database	Identifier
Smiles:	COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)CC(CO)O)NC3=C(C=C(C=C3)I)F)F)F
Inchikey:	RDSACQWTXKSHJT-NSHDSACASA-N
Pubchem:	44182295

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to RDEA119

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	TGFBR2	GDSC1000	pan-cancer	AAC	0.21	4e-11
mRNA	ALDH3B1	GDSC1000	pan-cancer	AAC	0.22	4e-11
mRNA	TGFBI	GDSC1000	pan-cancer	AAC	0.25	4e-11
mRNA	STRBP	GDSC1000	pan-cancer	AAC	-0.24	5e-11
mRNA	PLEC	GDSC1000	pan-cancer	AAC	0.23	5e-11
mRNA	ARHGAP18	GDSC1000	pan-cancer	AAC	0.21	6e-11
mRNA	ARMC12	GDSC1000	pan-cancer	AAC	-0.21	7e-11
mRNA	MYEF2	GDSC1000	pan-cancer	AAC	-0.22	7e-11
mRNA	NQO1	GDSC1000	pan-cancer	AAC	0.26	7e-11
mRNA	FAM46A	GDSC1000	pan-cancer	AAC	0.21	7e-11

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