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ABT-263

Synonyms

SourcesNames Used
GDSC1000, FIMMNavitoclax
CTRPv2navitoclax
PharmacoGx ABT-263

External IDs

DatabaseIdentifier
Smiles: CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey: JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem: 24978538

Annotated Targets

BCL2, BCL2L2, BAD

FDA Approval Status

Not Approved
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Top molecular features associated with response to ABT-263


Feature TypeStandardized
Nominal ANOVA
mRNA SETD4 CTRPv2 pan-cancer AAC 0.12 0.0009
mRNA PDX1 FIMM pan-cancer AAC 0.47 0.0009
mRNA MRPL40 CTRPv2 pan-cancer AAC -0.12 0.0009
mRNA GPR174 CTRPv2 pan-cancer AAC 0.12 0.0009
mRNA HOXD10 CTRPv2 pan-cancer AAC 0.13 0.0009
mRNA FKBP10 CTRPv2 pan-cancer AAC -0.13 0.0009
mRNA NAA16 CTRPv2 pan-cancer AAC 0.12 0.0009
mRNA YEATS4 FIMM pan-cancer AAC 0.52 0.0009
mRNA KLHL14 CTRPv2 pan-cancer AAC 0.12 0.0009
mRNA RPL27 CTRPv2 pan-cancer AAC -0.13 0.0008
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