PharmacoDB

Sources

Names Used

Navitoclax

navitoclax

PharmacoGx

ABT-263

Database	Identifier
Smiles:	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey:	JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem:	24978538

Database

Identifier

Smiles:

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Inchikey:

JLYAXFNOILIKPP-KXQOOQHDSA-N

Pubchem:

Top molecular features associated with response to ABT-263

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	C14orf180	CTRPv2	pan-cancer	AAC	0.12	0.0008
mRNA	SORCS3	CTRPv2	pan-cancer	AAC	0.12	0.0008
mRNA	PPCDC	CTRPv2	pan-cancer	AAC	-0.12	0.0008
mRNA	NSA2	CTRPv2	pan-cancer	AAC	-0.12	0.0008
mRNA	DSCR3	CTRPv2	pan-cancer	AAC	0.12	0.0008
mRNA	AHCY	CTRPv2	pan-cancer	AAC	-0.12	0.0008
mRNA	CXCR4	CTRPv2	pan-cancer	AAC	0.14	0.0008
mRNA	SCGB3A1	CTRPv2	pan-cancer	AAC	0.11	0.0008
mRNA	CEP162	CTRPv2	pan-cancer	AAC	0.12	0.0008
mRNA	NOVA2	CTRPv2	pan-cancer	AAC	0.14	0.0008