PharmacoDB

Sources

Names Used

Navitoclax

navitoclax

PharmacoGx

ABT-263

Database	Identifier
Smiles:	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey:	JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem:	24978538

Database

Identifier

Smiles:

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Inchikey:

JLYAXFNOILIKPP-KXQOOQHDSA-N

Pubchem:

Top molecular features associated with response to ABT-263

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	SCAMP3	CTRPv2	pan-cancer	AAC	-0.18	5e-07
mRNA	PRKAR2A	CTRPv2	pan-cancer	AAC	-0.18	1e-06
mRNA	PRELID1	CTRPv2	pan-cancer	AAC	-0.18	4e-07
mRNA	COPS2	CTRPv2	pan-cancer	AAC	-0.18	3e-07
mRNA	POU2AF1	CTRPv2	pan-cancer	AAC	-0.18	7e-06
mRNA	SEPT10	CTRPv2	pan-cancer	AAC	-0.18	2e-05
mRNA	DEF8	CTRPv2	pan-cancer	AAC	-0.18	2e-07
mRNA	MRPS18B	CTRPv2	pan-cancer	AAC	-0.18	4e-07
mRNA	CHCHD10	CTRPv2	pan-cancer	AAC	-0.18	7e-07
mRNA	GCSH	CTRPv2	pan-cancer	AAC	-0.18	5e-07