PharmacoDB

Sources

Names Used

Navitoclax

navitoclax

PharmacoGx

ABT-263

Database	Identifier
Smiles:	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey:	JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem:	24978538

Database

Identifier

Smiles:

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Inchikey:

JLYAXFNOILIKPP-KXQOOQHDSA-N

Pubchem:

Top molecular features associated with response to ABT-263

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZSCAN12	CTRPv2	pan-cancer	AAC	0.14	0.0002
mRNA	ZSCAN18	CTRPv2	pan-cancer	AAC	0.15	7e-05
mRNA	ZSCAN2	CTRPv2	pan-cancer	AAC	0.24	4e-10
mRNA	ZSCAN23	CTRPv2	pan-cancer	AAC	0.19	3e-06
mRNA	ZSCAN25	CTRPv2	pan-cancer	AAC	0.15	6e-05
mRNA	ZSCAN30	CTRPv2	pan-cancer	AAC	0.18	5e-07
mRNA	ZSCAN5A	CTRPv2	pan-cancer	AAC	0.14	7e-05
mRNA	ZSWIM4	CTRPv2	pan-cancer	AAC	0.12	0.0007
mRNA	ZSWIM5	CTRPv2	pan-cancer	AAC	0.14	0.0002
mRNA	ZZEF1	CTRPv2	pan-cancer	AAC	0.14	0.0001