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Bosutinib

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMBosutinib
CTRPv2bosutinib
PharmacoGx Bosutinib

External IDs

DatabaseIdentifier
Smiles: CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Inchikey: UBPYILGKFZZVDX-UHFFFAOYSA-N
Pubchem: 5328940

Annotated Targets

SRC, HCK, ABL1, BCR, CAMK1D, CAMK2G, CDK2, FRK, FYN, LYN, MAP2K1, MAP2K2, MAP3K2, MAP4K5, STK10, STK24, STK4, TNK2, TXK

Cell lines tested with Bosutinib

1269 cell lines have been tested with this compound, using data from 4 dataset(s).
BT-474 breast GDSC1000, GRAY, CTRPv25
MDA-MB-361 breast GDSC1000, GRAY, CTRPv25
Hs-578-T breast GDSC1000, GRAY, FIMM, CTRPv25
HCC1428 breast GDSC1000, GRAY, CTRPv24
HCC1395 breast GDSC1000, GRAY, CTRPv24
MDA-MB-175-VII breast GDSC1000, GRAY4
MDA-MB-415 breast GDSC1000, GRAY, CTRPv24
A549 lung GDSC1000, CTRPv24
HCC38 breast GDSC1000, GRAY, CTRPv24
BT-20 breast GDSC1000, GRAY, CTRPv24
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Top molecular features associated with response to Bosutinib


Feature TypeStandardized
Nominal ANOVA
mRNA CFAP161 GDSC1000 AAC 0.18 1e-08
mRNA SIGLEC6 GDSC1000 AAC 0.18 4e-08
mRNA NOD1 CTRPv2 AAC 0.18 7e-08
mRNA VPS26A GDSC1000 AAC 0.18 2e-07
mRNA DYNLT3 CTRPv2 AAC -0.2 3e-07
mRNA EGFR GDSC1000 AAC 0.21 3e-07
mRNA SMAGP GDSC1000 AAC 0.2 5e-07
mRNA PRSS57 GDSC1000 AAC 0.17 1e-06
mRNA PDPK1 GDSC1000 AAC -0.16 2e-06
mRNA PIM1 CTRPv2 AAC 0.17 2e-06
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