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Bortezomib

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMBortezomib
gCSI, CTRPv2bortezomib
PharmacoGx Bortezomib

External IDs

DatabaseIdentifier
Smiles: B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
Inchikey: GXJABQQUPOEUTA-RDJZCZTQSA-N
Pubchem: 387447

Annotated Targets

PSMB2, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB10, PSMB11, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9, PSMD1, PSMD2, RELA

Cell lines tested with Bortezomib

1148 cell lines have been tested with this compound, using data from 5 dataset(s).
MDA-MB-231 breast gCSI, GRAY, FIMM, CTRPv28
Hs-578-T breast gCSI, GRAY, FIMM, CTRPv28
BT-474 breast GDSC1000, gCSI, GRAY, FIMM, CTRPv28
HCC1428 breast GRAY, CTRPv27
T47D breast gCSI, GRAY, FIMM, CTRPv27
HCC1419 breast gCSI, GRAY, CTRPv27
BT-549 breast gCSI, GRAY, FIMM, CTRPv27
SK-BR-3 breast gCSI, GRAY, FIMM, CTRPv26
MDA-MB-453 breast gCSI, GRAY, FIMM, CTRPv26
MDA-MB-157 breast gCSI, GRAY, CTRPv26
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Top molecular features associated with response to Bortezomib


Feature TypeStandardized
Nominal ANOVA
mRNA C15orf38-AP3S2 CTRPv2 AAC -0.19 4e-07
mRNA PARP6 GDSC1000 AAC -0.27 5e-07
mRNA SOX4 CTRPv2 AAC 0.17 1e-06
mRNA MTURN CTRPv2 AAC 0.16 3e-06
mRNA PRLH CTRPv2 AAC -0.16 3e-06
mRNA CHMP4A CTRPv2 AAC -0.17 4e-06
mRNA IRAK1BP1 CTRPv2 AAC 0.17 4e-06
mRNA CCND1 CTRPv2 AAC -0.17 6e-06
mRNA UGDH CTRPv2 AAC -0.16 6e-06
mRNA SMARCC1 CTRPv2 AAC 0.18 7e-06
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