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BMS-536924

Synonyms

SourcesNames Used
GDSC1000, CTRPv2BMS-536924
PharmacoGx BMS-536924

External IDs

DatabaseIdentifier
Smiles: CC1=CC(=CC2=C1NC(=C3C(=CC=NC3=O)NCC(C4=CC(=CC=C4)Cl)O)N2)N5CCOCC5
Inchikey: UGQMURPIMYALPH-PZJQAWQVSA-N
Pubchem: 10390396

Annotated Targets

AKT1, CCNE1, CDK2, CYP3A4, ERBB2, IGF1R, KDR, LCK, MAPK1, MET, PDGFRA, PDGFRB, INSR

Cell lines tested with BMS-536924

1306 cell lines have been tested with this compound, using data from 2 dataset(s).
A549 lung GDSC1000, CTRPv24
NCI-H1869 lung GDSC1000, CTRPv24
LOXIMVI haematopoietic and lymphoid tissue GDSC1000, CTRPv24
NCI-H460 lung GDSC1000, CTRPv23
IGROV-1 ovary GDSC1000, CTRPv23
A375 skin GDSC1000, CTRPv23
NCI-H1299 lung GDSC1000, CTRPv23
OAW-28 ovary GDSC1000, CTRPv23
CCF-STTG1 central nervous system GDSC1000, CTRPv23
DU-145 prostate GDSC1000, CTRPv23
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Top molecular features associated with response to BMS-536924


Feature TypeStandardized
Nominal ANOVA
mRNA PPP1R27 GDSC1000 AAC 0.23 7e-13
mRNA PRDM1 CTRPv2 AAC 0.25 1e-11
mRNA WNT10B GDSC1000 AAC 0.2 2e-10
mRNA ZNF740 CTRPv2 AAC 0.22 6e-10
mRNA IGF1R GDSC1000 AAC 0.21 6e-10
mRNA CD79A CTRPv2 AAC -0.24 2e-09
mRNA IL6R CTRPv2 AAC 0.22 2e-09
mRNA SPCS1 CTRPv2 AAC 0.21 3e-09
mRNA RP4-583P15.14 CTRPv2 AAC 0.22 3e-09
mRNA SELPLG CTRPv2 AAC 0.23 6e-09
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