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BIX02189

Synonyms

SourcesNames Used
GDSC1000BIX02189
PharmacoGx BIX02189

External IDs

DatabaseIdentifier
Smiles: CN(C)Cc1cccc(NC(c2ccccc2)=C2/C(=O)Nc3cc(ccc23)C(=O)N(C)C)c1
Pubchem: 46931012

Annotated Targets

MAP2K5, MAPK7

Cell lines tested with BIX02189

978 cell lines have been tested with this compound, using data from 1 dataset(s).
MMAC-SF skin GDSC10001
A375 skin GDSC10001
OC-314 ovary GDSC10001
ESO26 oesophagus GDSC10001
A427 lung GDSC10001
KMS-12-BM haematopoietic and lymphoid tissue GDSC10001
NMC-G1 central nervous system GDSC10001
TOV-21G ovary GDSC10001
CMK haematopoietic and lymphoid tissue GDSC10001
CHSA0011 bone GDSC10001
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Top molecular features associated with response to BIX02189


Feature TypeStandardized
Nominal ANOVA
mRNA FLT3 GDSC1000 AAC 0.2 3e-10
mRNA CCR2 GDSC1000 AAC 0.19 8e-10
mRNA RNASE6 GDSC1000 AAC 0.21 1e-09
mRNA RASGRP2 GDSC1000 AAC 0.26 2e-09
mRNA C1orf228 GDSC1000 AAC 0.21 2e-09
mRNA PTPN7 GDSC1000 AAC 0.3 3e-09
mRNA GAB3 GDSC1000 AAC 0.22 4e-09
mRNA MYB GDSC1000 AAC 0.27 6e-09
mRNA LPAR4 GDSC1000 AAC 0.18 1e-08
mRNA C16orf54 GDSC1000 AAC 0.22 2e-08
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