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BIX02189

Synonyms

SourcesNames Used
GDSC1000BIX02189
PharmacoGx BIX02189

External IDs

DatabaseIdentifier
Smiles: CN(C)Cc1cccc(NC(c2ccccc2)=C2/C(=O)Nc3cc(ccc23)C(=O)N(C)C)c1
Pubchem: 46931012

Annotated Targets

MAP2K5, MAPK7

Cell lines tested with BIX02189

978 cell lines have been tested with this compound, using data from 1 dataset(s).
NCI-H2452 pleura GDSC10001
HCC2218 breast GDSC10001
P3HR-1 haematopoietic and lymphoid tissue GDSC10001
SNU-182 liver GDSC10001
COR-L303 lung GDSC10001
RH-41 soft tissue GDSC10001
DOK upper aerodigestive tract GDSC10001
LN-229 central nervous system GDSC10001
KYSE-450 oesophagus GDSC10001
MEC-1 haematopoietic and lymphoid tissue GDSC10001
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Top molecular features associated with response to BIX02189


Feature TypeStandardized
Nominal ANOVA
mRNA PRSS57 GDSC1000 AAC 0.28 1e-16
mRNA MLC1 GDSC1000 AAC 0.26 1e-14
mRNA MS4A6A GDSC1000 AAC 0.24 3e-14
mRNA PPP1R27 GDSC1000 AAC 0.23 4e-14
mRNA LAIR1 GDSC1000 AAC 0.3 2e-13
mRNA AIF1 GDSC1000 AAC 0.27 2e-13
mRNA LST1 GDSC1000 AAC 0.27 3e-13
mRNA GIMAP6 GDSC1000 AAC 0.21 8e-11
mRNA CSF1R GDSC1000 AAC 0.2 2e-10
mRNA CD33 GDSC1000 AAC 0.21 2e-10
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