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BIBW2992

Synonyms

SourcesNames Used
GDSC1000, FIMMAfatinib
GRAYBIBW2992
CTRPv2afatinib
PharmacoGx BIBW2992

External IDs

DatabaseIdentifier
Smiles: CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
Inchikey: ULXXDDBFHOBEHA-CWDCEQMOSA-N
Pubchem: 10184653

Cell lines tested with BIBW2992

1287 cell lines have been tested with this compound, using data from 4 dataset(s).
BT-474 breast GDSC1000, GRAY, FIMM, CTRPv27
MDA-MB-231 breast GDSC1000, GRAY, FIMM, CTRPv26
HCC1395 breast GDSC1000, GRAY, CTRPv25
MDA-MB-453 breast GDSC1000, GRAY, FIMM, CTRPv25
IGROV-1 ovary GDSC1000, FIMM, CTRPv25
BT-549 breast GDSC1000, GRAY, FIMM, CTRPv25
HCC1143 breast GDSC1000, GRAY, FIMM, CTRPv25
A549 lung GDSC1000, CTRPv25
Hs-578-T breast GDSC1000, GRAY, FIMM, CTRPv25
HCC1937 breast GDSC1000, GRAY, FIMM, CTRPv25
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Top molecular features associated with response to BIBW2992


Feature TypeStandardized
Nominal ANOVA
mRNA LAD1 CTRPv2 AAC 0.35 4e-16
mRNA ERBB2 CTRPv2 AAC 0.29 5e-15
mRNA PKP3 CTRPv2 AAC 0.36 2e-13
mRNA S100A14 CTRPv2 AAC 0.28 2e-12
mRNA CDS1 CTRPv2 AAC 0.28 5e-11
mRNA FAM83H CTRPv2 AAC 0.29 2e-10
mRNA CLDN4 CTRPv2 AAC 0.26 3e-10
mRNA MUC22 CTRPv2 AAC 0.22 5e-10
mRNA PRR5-ARHGAP8 CTRPv2 AAC 0.28 6e-10
mRNA GALNT3 CTRPv2 AAC 0.26 6e-10
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