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ZM-447439

Synonyms

SourcesNames Used
GDSC1000ZM-447439
GRAYZM447439
PharmacoGx ZM-447439

External IDs

DatabaseIdentifier
Smiles: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5
Inchikey: OGNYUTNQZVRGMN-UHFFFAOYSA-N
Pubchem: 9914412

Annotated Targets

AURKA, AURKB

Cell lines tested with ZM-447439

865 cell lines have been tested with this compound, using data from 2 dataset(s).
MDA-MB-361 breast GDSC1000, GRAY4
BT-474 breast GDSC1000, GRAY4
UACC-812 breast GRAY3
MX-1 breast GRAY3
MDA-MB-175-VII breast GRAY3
MDA-MB-134-VI breast GRAY3
CAMA-1 breast GRAY3
HCC1187 breast GDSC1000, GRAY3
HCC1428 breast GDSC1000, GRAY3
HCC1395 breast GDSC1000, GRAY3
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Top molecular features associated with response to ZM-447439


Feature TypeStandardized
Nominal ANOVA
mRNA GNA15 GDSC1000 AAC 0.3 3e-13
mRNA ZNF445 GDSC1000 AAC 0.29 5e-12
mRNA ATOX1 GDSC1000 AAC -0.26 7e-11
mRNA ADARB1 GDSC1000 AAC 0.23 4e-10
mRNA SPNS3 GDSC1000 AAC 0.25 5e-10
mRNA TOP1MT GDSC1000 AAC 0.22 6e-10
mRNA ADPRH GDSC1000 AAC -0.24 7e-10
mRNA MYB GDSC1000 AAC 0.33 8e-10
mRNA LAIR1 GDSC1000 AAC 0.28 2e-09
mRNA CD96 GDSC1000 AAC 0.23 5e-09
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