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VX-702

Synonyms

SourcesNames Used
GDSC1000VX-702
PharmacoGx VX-702

External IDs

DatabaseIdentifier
Smiles: C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F
Inchikey: FYSRKRZDBHOFAY-UHFFFAOYSA-N
Pubchem: 10341154

Annotated Targets

MAPK11, MAPK12, MAPK14, TNF, IL1B, IL6

Cell lines tested with VX-702

895 cell lines have been tested with this compound, using data from 1 dataset(s).
TE-12 oesophagus GDSC10001
C-4 I cervix GDSC10001
NCI-H64 lung GDSC10001
ROS-50 haematopoietic and lymphoid tissue GDSC10001
Geo large intestine GDSC10001
YT haematopoietic and lymphoid tissue GDSC10001
NCI-H720 lung GDSC10001
CP66-MEL skin GDSC10001
L-540 haematopoietic and lymphoid tissue GDSC10001
SAS upper aerodigestive tract GDSC10001
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Top molecular features associated with response to VX-702


Feature TypeStandardized
Nominal ANOVA
mRNA GUCA2B GDSC1000 AAC 0.19 2e-08
mRNA NNAT GDSC1000 AAC 0.18 3e-07
mRNA ZNF407 GDSC1000 AAC 0.19 8e-07
mRNA NPW GDSC1000 AAC 0.17 3e-06
mRNA RNASE6 GDSC1000 AAC 0.16 3e-05
mRNA NXPH1 GDSC1000 AAC 0.14 3e-05
mRNA CBLN4 GDSC1000 AAC 0.14 4e-05
mRNA VWA3A GDSC1000 AAC -0.14 5e-05
mRNA OR5M10 GDSC1000 AAC 0.14 7e-05
mRNA POLG2 GDSC1000 AAC 0.15 8e-05
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