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VX-680

Synonyms

SourcesNames Used
GDSC1000, GRAY, CTRPv2VX-680
PharmacoGx VX-680

External IDs

DatabaseIdentifier
Smiles: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
Inchikey: GCIKSSRWRFVXBI-UHFFFAOYSA-N
Pubchem: 5494449

Annotated Targets

AURKA, AURKB, AURKC

Cell lines tested with VX-680

575 cell lines have been tested with this compound, using data from 3 dataset(s).
184A1 breast GRAY1
184B5 breast GRAY1
2004 N/A CTRPv21
42-MG-BA central nervous system CTRPv21
600MPE breast GRAY1
697 haematopoietic and lymphoid tissue GDSC10001
8-MG-BA central nervous system GDSC10001
A101D skin GDSC10001
A204 soft tissue CTRPv21
A253 skin GDSC10001
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Top molecular features associated with response to VX-680


Feature TypeStandardized
Nominal ANOVA
mRNA JARID2 GDSC1000 AAC 0.37 5e-11
mRNA GNA15 GDSC1000 AAC 0.33 9e-09
mRNA MYB GDSC1000 AAC 0.39 1e-07
mRNA HNRNPDL CTRPv2 AAC 0.58 2e-07
mRNA ANKLE2 GDSC1000 AAC 0.27 2e-07
mRNA CCND3 GDSC1000 AAC 0.31 3e-07
mRNA FAM175A CTRPv2 AAC 0.57 3e-07
mRNA RBMX CTRPv2 AAC 0.54 5e-07
mRNA TRIM13 GDSC1000 AAC 0.27 5e-07
mRNA TTF1 GDSC1000 AAC 0.26 6e-07
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