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VX-680

Synonyms

SourcesNames Used
GDSC1000, GRAY, CTRPv2VX-680
PharmacoGx VX-680

External IDs

DatabaseIdentifier
Smiles: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
Inchikey: GCIKSSRWRFVXBI-UHFFFAOYSA-N
Pubchem: 5494449

Annotated Targets

AURKA, AURKB, AURKC

Cell lines tested with VX-680

575 cell lines have been tested with this compound, using data from 3 dataset(s).
NMC-G1 central nervous system GDSC10001
BT-474 breast GDSC1000, GRAY, CTRPv25
EB-3 haematopoietic and lymphoid tissue GDSC10001
SR haematopoietic and lymphoid tissue GDSC10001
NB69 autonomic ganglia GDSC10001
HCE-4 oesophagus GDSC10001
NCI-H82 lung GDSC10001
NB1 autonomic ganglia GDSC10001
CCRF-CEM haematopoietic and lymphoid tissue GDSC10001
HCC2218 breast GDSC1000, CTRPv22
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Top molecular features associated with response to VX-680


Feature TypeStandardized
Nominal ANOVA
mRNA ARHGAP40 CTRPv2 AAC 1e-05 1
mRNA GPR65 CTRPv2 AAC 9.9e-06 1
mRNA ZNF385B CTRPv2 AAC 8e-06 1
mRNA OR5AC2 GDSC1000 AAC 2.4e-06 1
mRNA METTL23 CTRPv2 AAC 5e-06 1
mRNA OR2D3 CTRPv2 AAC 4.9e-06 1
mRNA NAV3 GDSC1000 AAC 2.1e-06 1
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