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VX-680

Synonyms

SourcesNames Used
GDSC1000, GRAY, CTRPv2VX-680
PharmacoGx VX-680

External IDs

DatabaseIdentifier
Smiles: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
Inchikey: GCIKSSRWRFVXBI-UHFFFAOYSA-N
Pubchem: 5494449

Annotated Targets

AURKA, AURKB, AURKC

Cell lines tested with VX-680

575 cell lines have been tested with this compound, using data from 3 dataset(s).
BT139 N/A CTRPv21
BT159 N/A CTRPv21
BT187 N/A CTRPv21
BT228 N/A CTRPv21
BT231 N/A CTRPv21
BT239 N/A CTRPv21
HS578BST N/A CTRPv21
BT248 N/A CTRPv21
BT131 N/A CTRPv21
BT147 N/A CTRPv21
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Top molecular features associated with response to VX-680


Feature TypeStandardized
Nominal ANOVA
mRNA PRPF4B GDSC1000 AAC 0.26 4e-06
mRNA ARID2 GDSC1000 AAC 0.27 6e-06
mRNA FUBP1 CTRPv2 AAC 0.45 6e-06
mRNA VPREB1 GDSC1000 AAC 0.24 6e-06
mRNA PNMA6A CTRPv2 AAC 0.48 7e-06
mRNA KIAA0101 CTRPv2 AAC 0.47 7e-06
mRNA GPR137 GDSC1000 AAC -0.23 7e-06
mRNA NELL2 CTRPv2 AAC 0.44 8e-06
mRNA PALM3 CTRPv2 AAC 0.47 8e-06
mRNA CACNA1G CTRPv2 AAC 0.44 8e-06
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