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VX-680

Synonyms

SourcesNames Used
GDSC1000, GRAY, CTRPv2VX-680
PharmacoGx VX-680

External IDs

DatabaseIdentifier
Smiles: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
Inchikey: GCIKSSRWRFVXBI-UHFFFAOYSA-N
Pubchem: 5494449

Annotated Targets

AURKA, AURKB, AURKC

Cell lines tested with VX-680

575 cell lines have been tested with this compound, using data from 3 dataset(s).
BT-474 breast GDSC1000, GRAY, CTRPv25
MDA-MB-361 breast GRAY, CTRPv24
MDA-MB-134-VI breast GDSC1000, GRAY4
MDA-MB-415 breast GRAY, CTRPv23
UACC-812 breast GRAY3
MX-1 breast GRAY3
MDA-MB-175-VII breast GRAY3
CAMA-1 breast GRAY3
HCC1187 breast GDSC1000, GRAY3
MDA-MB-453 breast GRAY, CTRPv22
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Top molecular features associated with response to VX-680


Feature TypeStandardized
Nominal ANOVA
mRNA A4GALT GDSC1000 AAC -0.1 0.06
mRNA A4GNT CTRPv2 AAC -0.096 0.5
mRNA A4GNT GDSC1000 AAC 0.019 0.7
mRNA AAAS CTRPv2 AAC 0.18 0.1
mRNA AAAS GDSC1000 AAC -0.01 0.8
mRNA AACS GDSC1000 AAC -0.076 0.2
mRNA AACS CTRPv2 AAC -0.092 0.4
mRNA AADAC GDSC1000 AAC -0.054 0.3
mRNA AADAC CTRPv2 AAC -0.08 0.5
mRNA AADACL2 CTRPv2 AAC 0.074 0.5
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