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  3. VX-680



SourcesNames Used
GDSC1000, GRAY, CTRPv2VX-680
PharmacoGx VX-680

External IDs

Smiles: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
Pubchem: 5494449

Annotated Targets


Cell lines tested with VX-680

575 cell lines have been tested with this compound, using data from 3 dataset(s).
LY2 breast GRAY2
Hs-578-T breast GRAY2
HCC70 breast GRAY2
HCC2185 breast GRAY2
HCC1569 breast GRAY2
HCC1428 breast GRAY2
BT-483 breast GRAY2
AU565 breast GRAY, CTRPv22
SUM225CWN breast GRAY2
SUM 159PT breast GRAY2
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Top molecular features associated with response to VX-680

Feature TypeStandardized
Nominal ANOVA
mRNA JARID2 GDSC1000 AAC 0.37 5e-11
mRNA GNA15 GDSC1000 AAC 0.33 9e-09
mRNA MYB GDSC1000 AAC 0.39 1e-07
mRNA HNRNPDL CTRPv2 AAC 0.58 2e-07
mRNA ANKLE2 GDSC1000 AAC 0.27 2e-07
mRNA CCND3 GDSC1000 AAC 0.31 3e-07
mRNA FAM175A CTRPv2 AAC 0.57 3e-07
mRNA RBMX CTRPv2 AAC 0.54 5e-07
mRNA TRIM13 GDSC1000 AAC 0.27 5e-07
mRNA TTF1 GDSC1000 AAC 0.26 6e-07
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