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VX-680

Synonyms

SourcesNames Used
GDSC1000, GRAY, CTRPv2VX-680
PharmacoGx VX-680

External IDs

DatabaseIdentifier
Smiles: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
Inchikey: GCIKSSRWRFVXBI-UHFFFAOYSA-N
Pubchem: 5494449

Annotated Targets

AURKA, AURKB, AURKC

Cell lines tested with VX-680

575 cell lines have been tested with this compound, using data from 3 dataset(s).
P3HR-1 haematopoietic and lymphoid tissue GDSC10001
KELLY autonomic ganglia GDSC10001
RPMI-8402 haematopoietic and lymphoid tissue GDSC10001
KG-1 haematopoietic and lymphoid tissue GDSC10001
EW-12 bone GDSC10001
SW872 soft tissue GDSC10001
MC116 haematopoietic and lymphoid tissue GDSC10001
COLO-684 endometrium GDSC10001
BE2-M17 autonomic ganglia GDSC10001
NCI-H1694 lung GDSC1000, CTRPv22
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Top molecular features associated with response to VX-680


Feature TypeStandardized
Nominal ANOVA
mRNA JARID2 GDSC1000 AAC 0.37 5e-11
mRNA GNA15 GDSC1000 AAC 0.33 9e-09
mRNA MYB GDSC1000 AAC 0.39 1e-07
mRNA HNRNPDL CTRPv2 AAC 0.58 2e-07
mRNA ANKLE2 GDSC1000 AAC 0.27 2e-07
mRNA CCND3 GDSC1000 AAC 0.31 3e-07
mRNA FAM175A CTRPv2 AAC 0.57 3e-07
mRNA RBMX CTRPv2 AAC 0.54 5e-07
mRNA TRIM13 GDSC1000 AAC 0.27 5e-07
mRNA TTF1 GDSC1000 AAC 0.26 6e-07
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