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Vandetanib

Synonyms

SourcesNames Used
CCLE, FIMMVandetanib
CTRPv2vandetanib
PharmacoGx Vandetanib

External IDs

DatabaseIdentifier
Smiles: CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC
Inchikey: UHTHHESEBZOYNR-UHFFFAOYSA-N
Pubchem: 3081361

Annotated Targets

SRC, TEK, EGFR, EPHA1, EPHA10, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, ERBB2, ERBB3, ERBB4, FLT1, FLT4, KDR, PTK6, RET, VEGFA

Cell lines tested with Vandetanib

906 cell lines have been tested with this compound, using data from 3 dataset(s).
A549 lung CCLE, CTRPv24
CAL-51 breast FIMM, CTRPv23
IGROV-1 ovary FIMM, CTRPv23
ZR-75-1 breast CCLE, FIMM, CTRPv23
T47D breast CCLE, FIMM, CTRPv23
SUIT-2 pancreas CCLE, CTRPv23
SK-OV-3 ovary CCLE, FIMM, CTRPv23
SK-BR-3 breast CCLE, FIMM, CTRPv23
SIG-M5 haematopoietic and lymphoid tissue CCLE, FIMM, CTRPv23
PC-3 prostate CCLE, FIMM, CTRPv23
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Top molecular features associated with response to Vandetanib


Feature TypeStandardized
Nominal ANOVA
mRNA CTSV CTRPv2 AAC 0.25 4e-10
mRNA KRT16 CCLE AAC 0.3 6e-10
mRNA EVPL CCLE AAC 0.3 2e-08
mRNA EGFR CTRPv2 AAC 0.21 3e-08
mRNA KLK7 CCLE AAC 0.27 3e-08
mRNA SLC39A2 CCLE AAC 0.25 6e-08
mRNA PRSS8 CCLE AAC 0.29 1e-07
mRNA GJB3 CTRPv2 AAC 0.24 1e-07
mRNA CDH3 CCLE AAC 0.29 1e-07
mRNA PTBP3 CCLE AAC 0.26 3e-07
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