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tivozanib

Synonyms

SourcesNames Used
GDSC1000Tivozanib
CTRPv2tivozanib
PharmacoGx tivozanib

External IDs

DatabaseIdentifier
Smiles: CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl
Inchikey: SPMVMDHWKHCIDT-UHFFFAOYSA-N
Pubchem: 9911830

Annotated Targets

FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB, FLT3

Cell lines tested with tivozanib

1282 cell lines have been tested with this compound, using data from 2 dataset(s).
A549 lung CTRPv23
CCF-STTG1 central nervous system GDSC1000, CTRPv23
NCI-H1869 lung GDSC1000, CTRPv23
OAW-28 ovary GDSC1000, CTRPv23
NCI-H460 lung GDSC1000, CTRPv23
LOXIMVI haematopoietic and lymphoid tissue GDSC1000, CTRPv23
CAL-51 breast GDSC1000, CTRPv23
A375 skin GDSC1000, CTRPv23
DU-145 prostate GDSC1000, CTRPv23
NCI-H520 lung GDSC1000, CTRPv23
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Top molecular features associated with response to tivozanib


Feature TypeStandardized
Nominal ANOVA
mRNA CISH CTRPv2 AAC 0.46 3e-38
mRNA TRH GDSC1000 AAC 0.35 7e-27
mRNA PIM1 CTRPv2 AAC 0.38 9e-26
mRNA PRSS57 CTRPv2 AAC 0.37 6e-25
mRNA VSIG4 GDSC1000 AAC 0.3 1e-19
mRNA PDGFRA CTRPv2 AAC 0.31 6e-19
mRNA RP11-231C18.3 CTRPv2 AAC 0.31 1e-18
mRNA PRSS57 GDSC1000 AAC 0.31 4e-17
mRNA CSF1R GDSC1000 AAC 0.28 8e-16
mRNA DCUN1D4 CTRPv2 AAC 0.28 2e-14
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