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temsirolimus

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMTemsirolimus
CTRPv2temsirolimus
PharmacoGx temsirolimus

External IDs

DatabaseIdentifier
Smiles: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC
Inchikey: CBPNZQVSJQDFBE-FUXHJELOSA-N
Pubchem: 6918289

Annotated Targets

MTOR

Cell lines tested with temsirolimus

1095 cell lines have been tested with this compound, using data from 4 dataset(s).
MDA-MB-231 breast GDSC1000, GRAY, FIMM, CTRPv25
BT-474 breast GDSC1000, GRAY, FIMM5
ZR-75-1 breast GRAY, FIMM, CTRPv24
MDA-MB-361 breast GDSC1000, GRAY4
MDA-MB-175-VII breast GDSC1000, GRAY4
HCC1395 breast GDSC1000, GRAY, CTRPv24
MCF7 breast GDSC1000, GRAY, FIMM, CTRPv24
IGROV-1 ovary GDSC1000, FIMM, CTRPv24
HCC1143 breast GDSC1000, GRAY, FIMM, CTRPv24
HCC1569 breast GDSC1000, GRAY, CTRPv24
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Top molecular features associated with response to temsirolimus


Feature TypeStandardized
Nominal ANOVA
mRNA SNAP23 GDSC1000 AAC 0.24 2e-10
mRNA COQ8A GDSC1000 AAC -0.23 4e-10
mRNA SGPP1 GDSC1000 AAC 0.2 2e-09
mRNA CERS6 GDSC1000 AAC -0.21 2e-09
mRNA IRS2 GDSC1000 AAC -0.22 3e-09
mRNA UFSP2 GDSC1000 AAC 0.2 4e-09
mRNA ONECUT2 GDSC1000 AAC -0.2 8e-09
mRNA PHAX GDSC1000 AAC 0.19 8e-09
mRNA TNFAIP8 GDSC1000 AAC 0.26 1e-08
mRNA CLDN3 GDSC1000 AAC -0.25 2e-08
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