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Sunitinib

Synonyms

SourcesNames Used
GDSC1000, FIMMSunitinib
CTRPv2sunitinib
PharmacoGx Sunitinib

External IDs

DatabaseIdentifier
Smiles: CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C
Inchikey: WINHZLLDWRZWRT-ATVHPVEESA-N
Pubchem: 5329102

Annotated Targets

CSF1R, KIT, FLT1, FLT3, KDR, PDGFRA, PDGFRB, FLT4

Cell lines tested with Sunitinib

1060 cell lines have been tested with this compound, using data from 3 dataset(s).
A549 lung CTRPv23
IGROV-1 ovary FIMM, CTRPv23
SKM-1 haematopoietic and lymphoid tissue GDSC1000, FIMM, CTRPv23
BT-474 breast GDSC1000, FIMM, CTRPv23
MONO-MAC-6 haematopoietic and lymphoid tissue GDSC1000, FIMM, CTRPv23
LOXIMVI haematopoietic and lymphoid tissue GDSC1000, CTRPv23
ES-2 ovary GDSC1000, FIMM, CTRPv23
CAL-148 breast GDSC1000, FIMM, CTRPv23
SIG-M5 haematopoietic and lymphoid tissue GDSC1000, FIMM, CTRPv23
DU-4475 breast GDSC1000, FIMM, CTRPv23
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Top molecular features associated with response to Sunitinib


Feature TypeStandardized
Nominal ANOVA
mRNA PRSS57 CTRPv2 AAC 0.39 3e-31
mRNA GOLGA8M CTRPv2 AAC 0.36 1e-27
mRNA TIFAB CTRPv2 AAC 0.35 3e-27
mRNA DCANP1 CTRPv2 AAC 0.35 9e-27
mRNA GOLGA8J CTRPv2 AAC 0.32 3e-21
mRNA ITGAL CTRPv2 AAC 0.34 8e-20
mRNA PPP1R27 GDSC1000 AAC 0.43 1e-19
mRNA CFD CTRPv2 AAC 0.3 5e-19
mRNA TIFAB GDSC1000 AAC 0.4 4e-18
mRNA PLPPR3 CTRPv2 AAC 0.29 4e-17
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