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SourcesNames Used
GDSC1000, CTRPv2SN-38
PharmacoGx SN-38

External IDs

Smiles: CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O
Pubchem: 104842

Annotated Targets


Cell lines tested with SN-38

1233 cell lines have been tested with this compound, using data from 2 dataset(s).
A549 lung GDSC1000, CTRPv24
NCI-H1869 lung GDSC1000, CTRPv23
AsPC-1 pancreas GDSC1000, CTRPv23
LOXIMVI haematopoietic and lymphoid tissue GDSC1000, CTRPv23
NCI-H460 lung GDSC1000, CTRPv23
OAW-28 ovary GDSC1000, CTRPv23
NCI-H1299 lung GDSC1000, CTRPv23
CCF-STTG1 central nervous system GDSC1000, CTRPv23
DU-145 prostate GDSC1000, CTRPv23
A375 skin GDSC1000, CTRPv23
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Top molecular features associated with response to SN-38

Feature TypeStandardized
Nominal ANOVA
mRNA SLFN11 GDSC1000 AAC 0.5 8e-48
mRNA SLFN11 CTRPv2 AAC 0.46 1e-36
mRNA ELAVL1 CTRPv2 AAC 0.31 3e-15
mRNA KHDRBS1 CTRPv2 AAC 0.29 3e-14
mRNA KLHL23 CTRPv2 AAC 0.29 4e-13
mRNA LMNB1 CTRPv2 AAC 0.28 1e-12
mRNA MPHOSPH9 CTRPv2 AAC 0.27 3e-12
mRNA STMN1 CTRPv2 AAC 0.26 3e-12
mRNA HMGB2 CTRPv2 AAC 0.3 7e-12
mRNA RSBN1 CTRPv2 AAC 0.26 7e-12
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