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Roscovitine

Synonyms

SourcesNames Used
GDSC1000Roscovitine
FIMMSeliciclib
PharmacoGx Roscovitine

External IDs

DatabaseIdentifier
Smiles: CCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
Inchikey: BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Pubchem: 160355

Annotated Targets

CDK2, CDK9

Cell lines tested with Roscovitine

448 cell lines have been tested with this compound, using data from 2 dataset(s).
KASUMI-1 haematopoietic and lymphoid tissue GDSC1000, FIMM2
RPMI-8226 haematopoietic and lymphoid tissue GDSC1000, FIMM2
CCRF-CEM haematopoietic and lymphoid tissue GDSC1000, FIMM2
ML-2 haematopoietic and lymphoid tissue GDSC1000, FIMM2
ES-2 ovary GDSC1000, FIMM2
SIG-M5 haematopoietic and lymphoid tissue GDSC1000, FIMM2
NOMO-1 haematopoietic and lymphoid tissue GDSC1000, FIMM2
SR haematopoietic and lymphoid tissue GDSC1000, FIMM2
DU-4475 breast GDSC1000, FIMM2
KGN ovary GDSC1000, FIMM2
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Top molecular features associated with response to Roscovitine


Feature TypeStandardized
Nominal ANOVA
mRNA TSC22D3 GDSC1000 AAC 0.24 5e-06
mRNA PTH1R GDSC1000 AAC 0.24 6e-06
mRNA ECM1 GDSC1000 AAC 0.24 1e-05
mRNA TGFB2 GDSC1000 AAC 0.26 2e-05
mRNA THAP12 GDSC1000 AAC -0.25 2e-05
mRNA CCDC149 GDSC1000 AAC 0.23 3e-05
mRNA ZNF365 GDSC1000 AAC 0.21 4e-05
mRNA EMSY GDSC1000 AAC -0.22 4e-05
mRNA DCAKD GDSC1000 AAC -0.23 4e-05
mRNA WDR26 GDSC1000 AAC 0.21 5e-05
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