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Pyrimethamine

Synonyms

SourcesNames Used
GDSC1000Pyrimethamine
PharmacoGx Pyrimethamine

External IDs

DatabaseIdentifier
Smiles: CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
Inchikey: WKSAUQYGYAYLPV-UHFFFAOYSA-N
Pubchem: 4993

Annotated Targets

DHFR, SLC47A1

Cell lines tested with Pyrimethamine

430 cell lines have been tested with this compound, using data from 1 dataset(s).
ST486 haematopoietic and lymphoid tissue GDSC10001
LNCaP-Clone-FGC prostate GDSC10001
DMS-114 lung GDSC10001
BE-13 haematopoietic and lymphoid tissue GDSC10001
NOMO-1 haematopoietic and lymphoid tissue GDSC10001
JJN-3 haematopoietic and lymphoid tissue GDSC10001
BE2-M17 autonomic ganglia GDSC10001
GT3TKB stomach GDSC10001
MN-60 haematopoietic and lymphoid tissue GDSC10001
OCI-AML3 haematopoietic and lymphoid tissue GDSC10001
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Top molecular features associated with response to Pyrimethamine


Feature TypeStandardized
Nominal ANOVA
mRNA ARG2 GDSC1000 AAC 0.26 6e-06
mRNA AGO3 GDSC1000 AAC 0.23 1e-05
mRNA NHSL1 GDSC1000 AAC 0.24 2e-05
mRNA TUBE1 GDSC1000 AAC 0.22 3e-05
mRNA FAM216B GDSC1000 AAC -0.21 6e-05
mRNA ZNF584 GDSC1000 AAC 0.2 7e-05
mRNA TRIB2 GDSC1000 AAC 0.24 9e-05
mRNA SARS GDSC1000 AAC 0.2 0.0001
mRNA NDUFS6 GDSC1000 AAC -0.21 0.0001
mRNA PHOX2A GDSC1000 AAC -0.43 0.0001
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