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PI-103

Synonyms

SourcesNames Used
GDSC1000, CTRPv2PI-103
PharmacoGx PI-103

External IDs

DatabaseIdentifier
Smiles: C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O
Inchikey: TUVCWJQQGGETHL-UHFFFAOYSA-N
Pubchem: 9884685

Annotated Targets

MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC

Cell lines tested with PI-103

1283 cell lines have been tested with this compound, using data from 2 dataset(s).
A549 lung CTRPv23
CCF-STTG1 central nervous system GDSC1000, CTRPv23
LOXIMVI haematopoietic and lymphoid tissue GDSC1000, CTRPv23
CAL-51 breast GDSC1000, CTRPv23
NCI-H1299 lung GDSC1000, CTRPv23
OAW-28 ovary GDSC1000, CTRPv23
NCI-H1869 lung GDSC1000, CTRPv23
HeLa cervix GDSC1000, CTRPv23
NCI-H460 lung GDSC1000, CTRPv23
DU-145 prostate GDSC1000, CTRPv23
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Top molecular features associated with response to PI-103


Feature TypeStandardized
Nominal ANOVA
mRNA NQO1 GDSC1000 AAC -0.33 6e-17
mRNA LTBR GDSC1000 AAC -0.28 4e-13
mRNA TCF4 CTRPv2 AAC 0.25 6e-11
mRNA ZNF627 GDSC1000 AAC 0.2 3e-10
mRNA FBXO10 CTRPv2 AAC 0.22 2e-09
mRNA MEX3A GDSC1000 AAC 0.21 2e-09
mRNA AKR1C2 GDSC1000 AAC -0.2 2e-09
mRNA AKR1C3 GDSC1000 AAC -0.2 2e-09
mRNA UGT1A10 CTRPv2 AAC -0.23 2e-09
mRNA ZCCHC7 GDSC1000 AAC 0.22 3e-09
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