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PD-0325901

Synonyms

SourcesNames Used
CCLE, GDSC1000PD-0325901
gCSIpd0325901
PharmacoGx PD-0325901

External IDs

DatabaseIdentifier
Smiles: C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O
Inchikey: SUDAHWBOROXANE-SECBINFHSA-N
Pubchem: 9826528

Annotated Targets

MAP2K1, MAP2K2

Cell lines tested with PD-0325901

1081 cell lines have been tested with this compound, using data from 3 dataset(s).
WM-115 skin CCLE, GDSC1000, gCSI3
VMRC-LCD lung CCLE, GDSC1000, gCSI3
UACC-62 haematopoietic and lymphoid tissue CCLE, GDSC1000, gCSI3
U-87-MG central nervous system CCLE, GDSC1000, gCSI3
TYK-nu ovary CCLE, GDSC1000, gCSI3
TOV-21G ovary CCLE, GDSC1000, gCSI3
TOV-112D ovary CCLE, GDSC1000, gCSI3
TC-71 bone CCLE, GDSC1000, gCSI3
T98G central nervous system CCLE, GDSC1000, gCSI3
T84 large intestine CCLE, GDSC1000, gCSI3
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Top molecular features associated with response to PD-0325901


Feature TypeStandardized
Nominal ANOVA
mRNA LTBR GDSC1000 AAC 0.41 1e-22
mRNA SPRY2 CCLE AAC 0.43 9e-21
mRNA TIMP1 GDSC1000 AAC 0.32 3e-20
mRNA S100A11 GDSC1000 AAC 0.34 2e-19
mRNA CD68 GDSC1000 AAC 0.31 6e-19
mRNA LMNA GDSC1000 AAC 0.37 1e-18
mRNA SPRY2 GDSC1000 AAC 0.31 1e-18
mRNA CD63 GDSC1000 AAC 0.36 2e-18
mRNA ACTN1 GDSC1000 AAC 0.36 2e-18
mRNA CTSB GDSC1000 AAC 0.33 3e-18
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