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Panobinostat

Synonyms

SourcesNames Used
CCLE, FIMMPanobinostat
GRAYLBH589
CTRPv2LBH-589
PharmacoGx Panobinostat

External IDs

DatabaseIdentifier
Smiles: CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO
Inchikey: FPOHNWQLNRZRFC-ZHACJKMWSA-N
Pubchem: 6918837

Annotated Targets

HDAC8, HDAC1, HDAC2, HDAC3, HDAC4, HDAC6, HDAC7, HDAC9, HDAC5, HDAC10

Cell lines tested with Panobinostat

948 cell lines have been tested with this compound, using data from 4 dataset(s).
BT-474 breast CCLE, GRAY, FIMM, CTRPv26
ZR-75-1 breast CCLE, GRAY, FIMM, CTRPv25
Hs-578-T breast CCLE, GRAY, FIMM, CTRPv25
MDA-MB-231 breast GRAY, FIMM, CTRPv24
T47D breast CCLE, GRAY, FIMM, CTRPv24
MDA-MB-453 breast CCLE, GRAY, FIMM, CTRPv24
IGROV-1 ovary CCLE, FIMM, CTRPv24
HCC1569 breast CCLE, GRAY, CTRPv24
HCC1395 breast CCLE, GRAY, CTRPv24
CAMA-1 breast CCLE, GRAY, CTRPv24
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Top molecular features associated with response to Panobinostat


Feature TypeStandardized
Nominal ANOVA
mRNA CYR61 CCLE AAC -0.41 3e-13
mRNA CBX2 CTRPv2 AAC 0.26 1e-12
mRNA MBTD1 CTRPv2 AAC 0.27 2e-12
mRNA MEX3A CTRPv2 AAC 0.28 2e-12
mRNA MYOF CTRPv2 AAC -0.27 3e-12
mRNA GPX8 CCLE AAC -0.41 3e-12
mRNA TMED7-TICAM2 CTRPv2 AAC -0.26 3e-12
mRNA EIF4EBP2 CCLE AAC 0.29 1e-11
mRNA CD109 CTRPv2 AAC -0.25 1e-11
mRNA RMND5A CTRPv2 AAC 0.25 2e-11
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