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paclitaxel

Synonyms

SourcesNames Used
CCLE, GDSC1000, GRAY, FIMM, UHNBreastPaclitaxel
gCSI, CTRPv2paclitaxel
PharmacoGx paclitaxel

External IDs

DatabaseIdentifier
Smiles: CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]4[C@@]5(CO[C@@H]5C[C@H](O)[C@@]4(C)C1=O)OC(=O)C)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c6ccccc6)c7ccccc7
Inchikey: RCINICONZNJXQF-MZXODVADSA-N
Pubchem: 36314

Annotated Targets

BCL2, MAP2, MAP4, MAPT, NR1I2, TLR4, TUBB, TUBB1

Cell lines tested with paclitaxel

1174 cell lines have been tested with this compound, using data from 7 dataset(s).
MDA-MB-453 breast CCLE, gCSI, GRAY, FIMM, CTRPv29
MDA-MB-231 breast gCSI, GRAY, FIMM, CTRPv2, UHNBreast8
MDA-MB-468 breast CCLE, gCSI, GRAY, FIMM, CTRPv28
HCC1806 breast CCLE, gCSI, GRAY, CTRPv2, UHNBreast8
HCC1187 breast CCLE, GDSC1000, gCSI, GRAY, UHNBreast8
BT-474 breast CCLE, GDSC1000, gCSI, GRAY, FIMM, CTRPv28
ZR-75-1 breast CCLE, GRAY, FIMM, CTRPv2, UHNBreast7
SK-BR-3 breast CCLE, gCSI, GRAY, FIMM7
MDA-MB-436 breast CCLE, gCSI, GRAY, FIMM7
MCF7 breast CCLE, gCSI, GRAY, FIMM, CTRPv27
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Top molecular features associated with response to paclitaxel


Feature TypeStandardized
Nominal ANOVA
mRNA CD63 CTRPv2 AAC -0.29 3e-13
mRNA ORC1 CCLE AAC 0.34 4e-13
mRNA SSRP1 CCLE AAC 0.31 2e-12
mRNA PRPF38A CTRPv2 AAC 0.25 2e-11
mRNA TAF5 CCLE AAC 0.33 2e-11
mRNA OIP5 CCLE AAC 0.3 3e-11
mRNA TRAPPC9 gCSI AAC -0.35 3e-11
mRNA PSMG3 CCLE AAC 0.3 4e-11
mRNA ADAT2 CCLE AAC 0.35 5e-11
mRNA SNRPA CCLE AAC 0.3 6e-11
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