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OSI-027

Synonyms

SourcesNames Used
GDSC1000, CTRPv2OSI-027
PharmacoGx OSI-027

External IDs

DatabaseIdentifier
Smiles: COc1cccc2cc([nH]c12)-c1nc([C@@H]2CC[C@@H](CC2)C(O)=O)n2ncnc(N)c12
Pubchem: 44224160

Annotated Targets

MTOR

Cell lines tested with OSI-027

1290 cell lines have been tested with this compound, using data from 2 dataset(s).
A549 lung CTRPv23
AsPC-1 pancreas GDSC1000, CTRPv23
OAW-28 ovary GDSC1000, CTRPv23
NCI-H1869 lung GDSC1000, CTRPv23
CCF-STTG1 central nervous system GDSC1000, CTRPv23
SUIT-2 pancreas GDSC1000, CTRPv23
LOXIMVI haematopoietic and lymphoid tissue GDSC1000, CTRPv23
DU-145 prostate GDSC1000, CTRPv23
NCI-H460 lung GDSC1000, CTRPv23
NCI-H1299 lung GDSC1000, CTRPv23
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Top molecular features associated with response to OSI-027


Feature TypeStandardized
Nominal ANOVA
mRNA NQO1 GDSC1000 AAC -0.34 3e-17
mRNA MYOF GDSC1000 AAC -0.29 1e-12
mRNA S100A6 GDSC1000 AAC -0.24 1e-10
mRNA MEX3A GDSC1000 AAC 0.23 2e-10
mRNA GCLM GDSC1000 AAC -0.21 2e-10
mRNA LMNA GDSC1000 AAC -0.25 3e-10
mRNA LTBR GDSC1000 AAC -0.24 1e-09
mRNA UGDH GDSC1000 AAC -0.2 1e-09
mRNA MAU2 GDSC1000 AAC 0.2 2e-09
mRNA FTL GDSC1000 AAC -0.19 2e-09
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