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SourcesNames Used
GDSC1000, FIMMOlaparib
PharmacoGx AZD-2281

External IDs

Smiles: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
Pubchem: 23725625

Cell lines tested with AZD-2281

1296 cell lines have been tested with this compound, using data from 3 dataset(s).
IGROV-1 ovary GDSC1000, FIMM, CTRPv25
A549 lung GDSC1000, CTRPv25
CAL-51 breast GDSC1000, FIMM, CTRPv25
NCI-H460 lung GDSC1000, CTRPv24
NCI-H1869 lung GDSC1000, CTRPv24
DU-4475 breast GDSC1000, FIMM, CTRPv24
RMG-I ovary GDSC1000, FIMM, CTRPv24
MDA-MB-453 breast GDSC1000, FIMM, CTRPv24
MONO-MAC-6 haematopoietic and lymphoid tissue GDSC1000, FIMM, CTRPv24
CAL-85-1 breast GDSC1000, FIMM, CTRPv24
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Top molecular features associated with response to AZD-2281

Feature TypeStandardized
Nominal ANOVA
mRNA YPEL1 CTRPv2 AAC 0.27 4e-14
mRNA RSBN1 CTRPv2 AAC 0.27 1e-13
mRNA KIAA0922 CTRPv2 AAC 0.29 2e-13
mRNA MSH6 CTRPv2 AAC 0.25 1e-12
mRNA UHRF1 CTRPv2 AAC 0.25 1e-12
mRNA FAM117B CTRPv2 AAC 0.26 2e-12
mRNA GPC2 CTRPv2 AAC 0.28 1e-11
mRNA MEX3A CTRPv2 AAC 0.28 3e-11
mRNA EBF1 CTRPv2 AAC 0.23 3e-11
mRNA WASF1 CTRPv2 AAC 0.25 3e-11
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