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SourcesNames Used
GRAYNutlin 3a
PharmacoGx Nutlin-3

External IDs

Smiles: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Pubchem: 216345

Annotated Targets

MDM2, TP53

Cell lines tested with Nutlin-3

926 cell lines have been tested with this compound, using data from 3 dataset(s).
Hs-578-T breast CCLE, GRAY, CTRPv28
HCC1954 breast CCLE, GRAY, CTRPv27
HCC1428 breast GRAY, CTRPv26
MDA-MB-453 breast CCLE, GRAY, CTRPv26
BT-20 breast CCLE, GRAY, CTRPv26
MDA-MB-361 breast GRAY, CTRPv25
MDA-MB-231 breast GRAY, CTRPv25
HCC202 breast GRAY, CTRPv25
HCC1419 breast GRAY, CTRPv25
ZR-75-1 breast CCLE, GRAY, CTRPv25
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Top molecular features associated with response to Nutlin-3

Feature TypeStandardized
Nominal ANOVA
mRNA CDKN1A CTRPv2 AAC 0.35 1e-23
mRNA BAX CTRPv2 AAC 0.33 1e-20
mRNA ZMAT3 CTRPv2 AAC 0.33 8e-19
mRNA RPS27L CTRPv2 AAC 0.33 9e-18
mRNA FDXR CTRPv2 AAC 0.28 1e-17
mRNA DDB2 CTRPv2 AAC 0.28 1e-16
mRNA EDA2R CTRPv2 AAC 0.3 1e-15
mRNA XPC CTRPv2 AAC 0.27 2e-14
mRNA SPATA18 CTRPv2 AAC 0.29 5e-14
mRNA RPL3 CTRPv2 AAC 0.31 6e-14
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