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AZ628

Synonyms

SourcesNames Used
GDSC1000AZ628
PharmacoGx AZ628

External IDs

DatabaseIdentifier
Smiles: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C
Inchikey: ZGBGPEDJXCYQPH-UHFFFAOYSA-N
Pubchem: 11676786

Annotated Targets

BRAF, RAF1

Cell lines tested with AZ628

429 cell lines have been tested with this compound, using data from 1 dataset(s).
L-363 haematopoietic and lymphoid tissue GDSC10001
SU-DHL-6 haematopoietic and lymphoid tissue GDSC10001
JVM-3 haematopoietic and lymphoid tissue GDSC10001
L-428 haematopoietic and lymphoid tissue GDSC10001
ACN autonomic ganglia GDSC10001
D-542MG central nervous system GDSC10001
BB49-HNC upper aerodigestive tract GDSC10001
TE-8 oesophagus GDSC10001
BE-13 haematopoietic and lymphoid tissue GDSC10001
KALS-1 central nervous system GDSC10001
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Top molecular features associated with response to AZ628


Feature TypeStandardized
Nominal ANOVA
mRNA ZNF777 GDSC1000 AAC 0.00011 1
mRNA DRAXIN GDSC1000 AAC 9.9e-05 1
mRNA SLC5A10 GDSC1000 AAC 9.6e-05 1
mRNA KDM5C GDSC1000 AAC -8.8e-05 1
mRNA TCHH GDSC1000 AAC -8.3e-05 1
mRNA NMT2 GDSC1000 AAC 9.7e-05 1
mRNA KPNA7 GDSC1000 AAC 6.6e-05 1
mRNA SEC31B GDSC1000 AAC -7e-05 1
mRNA MRPL37 GDSC1000 AAC -5.7e-05 1
mRNA USH2A GDSC1000 AAC 4.1e-05 1
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