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AZ628

Synonyms

SourcesNames Used
GDSC1000AZ628
PharmacoGx AZ628

External IDs

DatabaseIdentifier
Smiles: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C
Inchikey: ZGBGPEDJXCYQPH-UHFFFAOYSA-N
Pubchem: 11676786

Annotated Targets

BRAF, RAF1

Cell lines tested with AZ628

429 cell lines have been tested with this compound, using data from 1 dataset(s).
SK-N-FI autonomic ganglia GDSC10001
BE2-M17 autonomic ganglia GDSC10001
NB12 autonomic ganglia GDSC10001
NB69 autonomic ganglia GDSC10001
NB7 autonomic ganglia GDSC10001
MHH-NB-11 autonomic ganglia GDSC10001
NBsusSR autonomic ganglia GDSC10001
NB1 autonomic ganglia GDSC10001
GOTO autonomic ganglia GDSC10001
KELLY autonomic ganglia GDSC10001
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Top molecular features associated with response to AZ628


Feature TypeStandardized
Nominal ANOVA
mRNA DUSP6 GDSC1000 AAC 0.38 4e-15
mRNA SPRY4 GDSC1000 AAC 0.38 5e-13
mRNA RAB39B GDSC1000 AAC -0.37 2e-12
mRNA ETV5 GDSC1000 AAC 0.34 1e-11
mRNA LTBR GDSC1000 AAC 0.39 3e-11
mRNA OAF GDSC1000 AAC 0.34 5e-11
mRNA ST3GAL4 GDSC1000 AAC 0.34 2e-10
mRNA TYRP1 GDSC1000 AAC 0.32 7e-10
mRNA KIAA0930 GDSC1000 AAC 0.29 1e-09
mRNA CLEC11A GDSC1000 AAC 0.3 1e-09
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