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Nilotinib

Synonyms

SourcesNames Used
CCLE, GDSC1000, FIMMNilotinib
CTRPv2nilotinib
PharmacoGx Nilotinib

External IDs

DatabaseIdentifier
Smiles: CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5
Inchikey: HHZIURLSWUIHRB-UHFFFAOYSA-N
Pubchem: 644241

Annotated Targets

ABL1, KIT, BCR

Cell lines tested with Nilotinib

1260 cell lines have been tested with this compound, using data from 4 dataset(s).
IGROV-1 ovary CCLE, GDSC1000, FIMM, CTRPv25
A549 lung CCLE, GDSC1000, CTRPv25
CAL-51 breast GDSC1000, FIMM, CTRPv24
T47D breast CCLE, GDSC1000, FIMM, CTRPv24
SUIT-2 pancreas CCLE, GDSC1000, CTRPv24
SK-OV-3 ovary CCLE, GDSC1000, FIMM, CTRPv24
OVCAR-8 ovary CCLE, GDSC1000, FIMM, CTRPv24
OVCAR-4 ovary CCLE, GDSC1000, FIMM, CTRPv24
OV-90 ovary CCLE, GDSC1000, FIMM, CTRPv24
OCI-AML5 haematopoietic and lymphoid tissue CCLE, GDSC1000, FIMM, CTRPv24
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Top molecular features associated with response to Nilotinib


Feature TypeStandardized
Nominal ANOVA
mRNA CFAP161 GDSC1000 AAC 0.52 1e-55
mRNA PIM1 CTRPv2 AAC 0.52 5e-49
mRNA CISH CTRPv2 AAC 0.49 1e-43
mRNA PRSS57 GDSC1000 AAC 0.5 3e-42
mRNA APOL4 CCLE AAC 0.62 5e-41
mRNA APOL4 GDSC1000 AAC 0.47 2e-40
mRNA OSM GDSC1000 AAC 0.5 9e-40
mRNA CISH GDSC1000 AAC 0.48 3e-38
mRNA KLF1 GDSC1000 AAC 0.42 2e-34
mRNA RHD GDSC1000 AAC 0.39 8e-30
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