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MK-2206

Synonyms

SourcesNames Used
GDSC1000, CTRPv2MK-2206
PharmacoGx MK-2206

External IDs

DatabaseIdentifier
Smiles: C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl
Inchikey: HWUHTJIKQZZBRA-UHFFFAOYSA-N
Pubchem: 46930998

Annotated Targets

AKT2, AKT1, AKT3

Cell lines tested with MK-2206

1222 cell lines have been tested with this compound, using data from 2 dataset(s).
A549 lung GDSC1000, CTRPv24
LOXIMVI haematopoietic and lymphoid tissue GDSC1000, CTRPv23
CCF-STTG1 central nervous system GDSC1000, CTRPv23
NCI-H460 lung GDSC1000, CTRPv23
IGROV-1 ovary GDSC1000, CTRPv23
NCI-H520 lung GDSC1000, CTRPv23
OAW-28 ovary GDSC1000, CTRPv23
NCI-H1869 lung GDSC1000, CTRPv23
DU-145 prostate GDSC1000, CTRPv23
HeLa cervix GDSC1000, CTRPv23
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Top molecular features associated with response to MK-2206


Feature TypeStandardized
Nominal ANOVA
mRNA P2RY8 CTRPv2 AAC 0.33 5e-12
mRNA RP4-583P15.14 CTRPv2 AAC 0.25 1e-11
mRNA LIME1 CTRPv2 AAC 0.24 3e-11
mRNA E2F2 CTRPv2 AAC 0.27 4e-11
mRNA FAM214A CTRPv2 AAC 0.23 1e-09
mRNA FOXO1 CTRPv2 AAC 0.22 1e-09
mRNA RP4-583P15.15 CTRPv2 AAC 0.22 2e-09
mRNA CCDC117 CTRPv2 AAC 0.23 2e-09
mRNA PARP1 CTRPv2 AAC 0.24 3e-09
mRNA MAST3 CTRPv2 AAC 0.24 4e-09
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