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Midostaurin

Synonyms

SourcesNames Used
GDSC1000Midostaurin
PharmacoGx Midostaurin

External IDs

DatabaseIdentifier
Smiles: CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Inchikey: BMGQWWVMWDBQGC-PZFYLCKJSA-N
Pubchem: 24202429

Annotated Targets

KIT, FLT3, PRKCG

Cell lines tested with Midostaurin

941 cell lines have been tested with this compound, using data from 1 dataset(s).
SAS upper aerodigestive tract GDSC10001
Capan-2 pancreas GDSC10001
NCI-H650 lung GDSC10001
HSC-39 stomach GDSC10001
COLO-205 large intestine GDSC10001
NUGC-4 stomach GDSC10001
MLMA haematopoietic and lymphoid tissue GDSC10001
42-MG-BA central nervous system GDSC10001
PL4 pancreas GDSC10001
RERF-LC-MS lung GDSC10001
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Top molecular features associated with response to Midostaurin


Feature TypeStandardized
Nominal ANOVA
mRNA GLIPR1 GDSC1000 AAC 0.29 2e-14
mRNA MRC2 GDSC1000 AAC 0.29 7e-13
mRNA FOSL2 GDSC1000 AAC 0.27 6e-12
mRNA PTRF GDSC1000 AAC 0.29 9e-12
mRNA TIFAB GDSC1000 AAC 0.23 1e-11
mRNA OCSTAMP GDSC1000 AAC 0.23 1e-11
mRNA AXL GDSC1000 AAC 0.28 2e-11
mRNA CYR61 GDSC1000 AAC 0.32 4e-11
mRNA MYOF GDSC1000 AAC 0.3 5e-11
mRNA PLIN3 GDSC1000 AAC 0.24 8e-11
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