1. Home/
  2. Compounds/
  3. Methotrexate

Methotrexate

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMMethotrexate
CTRPv2methotrexate
PharmacoGx Methotrexate

External IDs

DatabaseIdentifier
Smiles: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Inchikey: FBOZXECLQNJBKD-ZDUSSCGKSA-N
Pubchem: 126941

Annotated Targets

DHFR

Cell lines tested with Methotrexate

1269 cell lines have been tested with this compound, using data from 4 dataset(s).
HCC1428 breast GDSC1000, GRAY, CTRPv26
Hs-578-T breast GDSC1000, GRAY, FIMM, CTRPv26
MDA-MB-231 breast GDSC1000, GRAY, FIMM, CTRPv26
BT-474 breast GDSC1000, GRAY, FIMM, CTRPv25
MCF7 breast GDSC1000, GRAY, FIMM, CTRPv25
BT-549 breast GDSC1000, GRAY, FIMM, CTRPv25
HCC1937 breast GDSC1000, GRAY, FIMM, CTRPv25
MDA-MB-361 breast GDSC1000, GRAY, CTRPv25
MDA-MB-453 breast GDSC1000, GRAY, FIMM, CTRPv25
BT-20 breast GDSC1000, GRAY, CTRPv25
Download CSV
Download Data as CSV

Top molecular features associated with response to Methotrexate


Feature TypeStandardized
Nominal ANOVA
mRNA HSPD1 CTRPv2 AAC 0.29 4e-15
mRNA KBTBD11 GDSC1000 AAC 0.24 6e-15
mRNA WDR12 CTRPv2 AAC 0.29 9e-14
mRNA C1QBP CTRPv2 AAC 0.27 2e-13
mRNA NOP58 CTRPv2 AAC 0.27 6e-13
mRNA NDUFAF4 CTRPv2 AAC 0.28 1e-12
mRNA GART CTRPv2 AAC 0.26 1e-12
mRNA KARS CTRPv2 AAC 0.25 5e-12
mRNA AURKB CTRPv2 AAC 0.25 7e-12
mRNA EXOSC8 CTRPv2 AAC 0.27 7e-12
Download CSV