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linifanib

Synonyms

SourcesNames Used
GDSC1000Linifanib
CTRPv2linifanib
PharmacoGx linifanib

External IDs

DatabaseIdentifier
Smiles: Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Pubchem: 11485656

Annotated Targets

CSF1R, CSF1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RET, TEK

Cell lines tested with linifanib

1283 cell lines have been tested with this compound, using data from 2 dataset(s).
A549 lung CTRPv23
LOXIMVI haematopoietic and lymphoid tissue GDSC1000, CTRPv23
NCI-H1869 lung GDSC1000, CTRPv23
P3HR-1 haematopoietic and lymphoid tissue GDSC1000, CTRPv23
NCI-H460 lung GDSC1000, CTRPv23
DU-145 prostate GDSC1000, CTRPv23
NCI-H1299 lung GDSC1000, CTRPv23
OAW-28 ovary GDSC1000, CTRPv23
AsPC-1 pancreas GDSC1000, CTRPv23
CCF-STTG1 central nervous system GDSC1000, CTRPv23
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Top molecular features associated with response to linifanib


Feature TypeStandardized
Nominal ANOVA
mRNA OCSTAMP GDSC1000 AAC 0.49 7e-49
mRNA TIFAB GDSC1000 AAC 0.46 9e-47
mRNA CD300LF GDSC1000 AAC 0.47 6e-41
mRNA CSF1R GDSC1000 AAC 0.45 9e-39
mRNA PPP1R27 GDSC1000 AAC 0.42 4e-37
mRNA FLT3 GDSC1000 AAC 0.43 6e-36
mRNA PRSS57 GDSC1000 AAC 0.45 7e-36
mRNA AZU1 GDSC1000 AAC 0.42 6e-35
mRNA CCR2 GDSC1000 AAC 0.39 4e-30
mRNA RNASE2 GDSC1000 AAC 0.39 7e-30
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