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SourcesNames Used
CCLE, GDSC1000, GRAY, FIMM, UHNBreastLapatinib
gCSI, CTRPv2lapatinib
PharmacoGx lapatinib

External IDs

Smiles: CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
Pubchem: 208908

Annotated Targets


Cell lines tested with lapatinib

1157 cell lines have been tested with this compound, using data from 7 dataset(s).
Hs-578-T breast CCLE, gCSI, GRAY, FIMM, CTRPv29
MDA-MB-453 breast CCLE, gCSI, GRAY, FIMM, CTRPv28
MDA-MB-157 breast CCLE, gCSI, GRAY, CTRPv2, UHNBreast7
HCC1954 breast CCLE, gCSI, GRAY, CTRPv27
HCC1187 breast CCLE, GDSC1000, gCSI, GRAY, UHNBreast7
BT-549 breast CCLE, gCSI, GRAY, FIMM, CTRPv2, UHNBreast7
MDA-MB-231 breast gCSI, GRAY, FIMM, CTRPv26
HCC1937 breast gCSI, GRAY, FIMM, CTRPv2, UHNBreast6
ZR-75-1 breast CCLE, GRAY, FIMM, CTRPv2, UHNBreast6
T47D breast CCLE, gCSI, GRAY, FIMM, CTRPv26
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Top molecular features associated with response to lapatinib

Feature TypeStandardized
Nominal ANOVA
mRNA ERBB2 CCLE AAC 0.57 3e-33
mRNA PGAP3 CCLE AAC 0.45 7e-26
mRNA GRB7 CCLE AAC 0.49 5e-24
mRNA ERBB2 gCSI AAC 0.51 1e-17
mRNA ERBB2 CTRPv2 AAC 0.31 1e-17
mRNA STARD3 CCLE AAC 0.36 3e-17
mRNA S100A14 CCLE AAC 0.43 4e-17
mRNA EPN3 CCLE AAC 0.43 8e-17
mRNA MAL2 CCLE AAC 0.47 4e-16
mRNA JUP CCLE AAC 0.41 2e-15
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