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Irinotecan

Synonyms

SourcesNames Used
CCLE, FIMMIrinotecan
gCSIirinotecan
GRAYCPT-11
PharmacoGx Irinotecan

External IDs

DatabaseIdentifier
Smiles: CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey: UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem: 60838

Annotated Targets

TOP1, TOP1MT

Cell lines tested with Irinotecan

583 cell lines have been tested with this compound, using data from 4 dataset(s).
MDA-MB-468 breast CCLE, gCSI, GRAY, FIMM8
HCC2185 breast GRAY7
MDA-MB-436 breast gCSI, GRAY, FIMM6
BT-474 breast gCSI, GRAY, FIMM6
SK-BR-3 breast CCLE, gCSI, GRAY, FIMM6
MDA-MB-453 breast CCLE, gCSI, GRAY, FIMM6
MCF7 breast CCLE, gCSI, GRAY, FIMM6
MDA-MB-361 breast GRAY5
MDA-MB-231 breast gCSI, GRAY, FIMM5
HCC1419 breast gCSI, GRAY5
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Top molecular features associated with response to Irinotecan


Feature TypeStandardized
Nominal ANOVA
mRNA SLFN11 gCSI AAC 0.46 2e-19
mRNA SLFN11 CCLE AAC 0.41 1e-14
mRNA HNRNPC gCSI AAC 0.34 4e-11
mRNA CPSF6 CCLE AAC 0.42 4e-10
mRNA SRSF3 gCSI AAC 0.33 4e-10
mRNA CD63 CCLE AAC -0.39 2e-09
mRNA SERBP1 gCSI AAC 0.3 3e-09
mRNA RFXAP CCLE AAC 0.37 4e-09
mRNA TAF5 CCLE AAC 0.34 4e-09
mRNA RBMX gCSI AAC 0.32 6e-09
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