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Imatinib

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMImatinib
CTRPv2imatinib
PharmacoGx Imatinib

External IDs

DatabaseIdentifier
Smiles: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
Inchikey: KTUFNOKKBVMGRW-UHFFFAOYSA-N
Pubchem: 5291

Annotated Targets

KIT, ABL1, CSF1R, DDR1, NTRK1, PDGFRA, PDGFRB, RET, BCR

Cell lines tested with Imatinib

1092 cell lines have been tested with this compound, using data from 4 dataset(s).
Hs-578-T breast GRAY, FIMM, CTRPv28
MDA-MB-453 breast GRAY, FIMM, CTRPv26
HCC1419 breast GRAY, CTRPv25
MDA-MB-361 breast GRAY, CTRPv25
MDA-MB-231 breast GRAY, FIMM, CTRPv25
HCC1954 breast GRAY, CTRPv25
HCC1428 breast GRAY, CTRPv25
BT-474 breast GDSC1000, GRAY, FIMM, CTRPv25
T47D breast GRAY, FIMM, CTRPv24
SK-BR-3 breast GRAY, FIMM, CTRPv24
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Top molecular features associated with response to Imatinib


Feature TypeStandardized
Nominal ANOVA
mRNA PIM1 CTRPv2 AAC 0.48 2e-42
mRNA CISH CTRPv2 AAC 0.45 4e-37
mRNA ANK1 CTRPv2 AAC 0.34 4e-23
mRNA SLC6A19 CTRPv2 AAC 0.33 9e-22
mRNA ACSM1 CTRPv2 AAC 0.31 4e-19
mRNA ADAT2 CTRPv2 AAC 0.36 6e-18
mRNA NFE2 CTRPv2 AAC 0.31 1e-17
mRNA KLF1 CTRPv2 AAC 0.3 2e-17
mRNA AC104389.1 CTRPv2 AAC 0.29 2e-17
mRNA FAM117A CTRPv2 AAC 0.36 2e-17
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